SF is so rich in restaurants, I think one could eat at a different place every day, three meals a day, for years without ever hitting the same place twice. It's just amazing (and mind boggling, if you don't know what you want and are trying to decide by looking in the phone book!).

One of my favorite SF joints is a Greek place called Kokkari. Pricey but worth the splurge.
www.kokkari.com

My hubby and I have recently discovered Alamo Square Seafood Grill. Great atmosphere and very reasonable prices. Bonus is that it's just one block down from the oft-photographed "Painted Ladies" (row of brightly colored Victorians with the city skyline in the background).
alamosquareseafoodgrill.com/index.php

Great little Spanish place on Lombard called Alegrias (real hole-in-the-wall kinda place). Excellent tapas and very friendly staff - they treat everyone like family. : )

Fuku-Sushi in the Japantown Center has always been good to us, although I see now that it's received some mixed reviews.

Best crab cocktail on the planet? Sabella & LaTorre on Taylor in Fisherman's Wharf.
www.bestofsanfrancisco.net/sabe...e.htm

I really could go on all day... ; )